Researchers discover a genetic mechanism that affects birth defects, some cancers

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Scientists have understood for some time that proper embryonic development depends in large part on transcriptional repressors, proteins that prevent genes from being expressed at inappropriate times. Steven Vokes, associate professor of molecular biosciences at the University of Texas at Austin, and his team focus on a set of proteins called GLI (glioma-associated oncogene) and how they control gene expression in response to what is known as the Hedgehog pathway.

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